abstract：:Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the pro...

journal_title：Journal of endocrinological investigation

authors： Watson J,Taylor M,Pampiglione J,Rasbridge S,Armitage M

更新日期：2001-11-01 00:00:00

abstract：:The aim of this study was to assess the early insulin secretion and insulin action of healthy non-diabetic Hispanic-Mexican subjects with and without family history of Type 2 diabetes (FHD). One hundred and twenty non-relative subjects were compared against 115 first-degree relatives of individuals with Type 2 diabete...

journal_title：Journal of endocrinological investigation

authors： Guerrer-Romer F,Rodríguez-Morán M,González-Ortiz M,Martínez-Abundis E

更新日期：2001-09-01 00:00:00

abstract：:IGF-I stimulates protein synthesis, lowers blood glucose, and affects cell differentiation. The main production site of IGF-I is the liver. One of its binding proteins, IGFBP-1, is also produced by the liver. It is well known that ethanol affects the function of the human liver. Long-term alcohol abuse may therefore n...

journal_title：Journal of endocrinological investigation

authors： Röjdmark S,Brismar K

更新日期：2001-07-01 00:00:00

abstract：:The underlying mechanism leading to carcinogenesis involves genomic instability, likely related to aneuploidy. While p53 as a "guardian of the genome" is an appealing candidate as an initiator of genomic instability, its mutations or deletions usually occur late in the course of tumor progression. P53 may, however, be...

journal_title：Journal of endocrinological investigation

authors： Farid NR

更新日期：2001-07-01 00:00:00

abstract：:We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadeno...

journal_title：Journal of endocrinological investigation

authors： Fujikawa M,Okamura K,Sato K,Shiratsuchi M,Yao T,Mizokami T,Fujishima M

更新日期：2001-06-01 00:00:00

abstract：UNLABELLED:Hypercalcemia occurring in patients with advanced breast cancer (BC) is generally due to osteolytic metastases or to the activity of circulating tumor-derived products. In these conditions, the production of endogenous PTH is reduced. The frequency of hypercalcemia due to primary hyperparathyroidism in breas...

journal_title：Journal of endocrinological investigation

authors： Fierabracci P,Pinchera A,Miccoli P,Conte PF,Vignali E,Zaccagnini M,Marcocci C,Giani C

更新日期：2001-05-01 00:00:00

abstract：:In 1992 a significant relationship between bone turnover and the vitamin D receptor (VDR) genotype was reported in Australian subjects of UK-Irish decent. Since then, several groups have investigated the relationship between VDR and other bone-related genotypes, bone mass and bone turnover in several populations. Howe...

journal_title：Journal of endocrinological investigation

authors： Sheehan D,Bennett T,Cashman KD

更新日期：2001-04-01 00:00:00

abstract：:A 36-year-old non-pregnant woman presented with a four-month history of progressive visual deterioration and amenorrhea. The latest gestation was 6 years earlier. Hormonal study revealed central diabetes insipidus, hypopituitarism, and slightly increased prolactin level. Ophthalmologic examination showed bilateral hem...

journal_title：Journal of endocrinological investigation

authors： Durán Martínez M,Santonja C,Pavón de Paz I,Monereo Megías S

更新日期：2001-03-01 00:00:00

abstract：:The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility. However, other genes have been recently mapped to this region and they could contribute to the AZFc phenotype. In particular, the testis-specific CDY1 (chromadomain protein 1) ...

journal_title：Journal of endocrinological investigation

authors： Ferlin A,Moro E,Rossi A,Foresta C

更新日期：2001-02-01 00:00:00

abstract：:Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes m...

journal_title：Journal of endocrinological investigation

authors： Martina V,Bruno GA,Zumpano E,Origlia C,Quaranta L,Pescarmona GP

更新日期：2001-01-01 00:00:00

abstract：:The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma. From 1992 to 1999, 39 consecutive patients with a histologically or cytologically proven anaplastic thyroid carcinoma were referred to the Thyroid Center of Padua General Hospital. There were 28 ...

journal_title：Journal of endocrinological investigation

authors： Busnardo B,Daniele O,Pelizzo MR,Mazzarotto R,Nacamulli D,Devido D,Mian C,Girelli ME

更新日期：2000-12-01 00:00:00

abstract：:The long arm of the Y chromosome contains genes mapped in loci involved in male infertility, short stature and gonadoblastoma. However, many of these genes have not been fully characterized, and are not currently investigated in patients affected by such diseases. We report a study aimed to the genomic characterizatio...

journal_title：Journal of endocrinological investigation

authors： Stuppia L,Gatta V,Fogh I,Gaspari AR,Grande R,Morizio E,Fantasia D,Pizzuti A,Calabrese G,Palka G

更新日期：2000-11-01 00:00:00

abstract：:Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...

journal_title：Journal of endocrinological investigation

authors： Beck-Peccoz P,Romoli R,Persani L

更新日期：2000-10-01 00:00:00

abstract：:The differential diagnosis of an osteoblastic vertebral lesion (ivory vertebra) includes metastatic prostate cancer, lung cancer, lymphoma, osteosarcoma and Paget's disease. We report a case of a man who was initially diagnosed with Paget's disease on vertebral biopsy. He failed to respond to conventional bisphosphate...

journal_title：Journal of endocrinological investigation

authors： Basaria S,McCarthy EF,Belzberg AJ,Ball DW

更新日期：2000-09-01 00:00:00

abstract：:The syndrome of apparent mineralocorticoid syndrome (AME) results from defective 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol to its inactive metabolite cortisone. Its deficiency allows the unmetabolized co...

journal_title：Journal of endocrinological investigation

authors： Palermo M,Delitala G,Sorba G,Cossu M,Satta R,Tedde R,Pala A,Shackleton CH

更新日期：2000-07-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

journal_title：Journal of endocrinological investigation

authors： Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

更新日期：2000-06-01 00:00:00

abstract：:Here we describe a subject with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-CAH), in its classical virilizing form, who presented at birth ambiguous genitalia and subsequently was assigned by the parents as male. At the age of 8 years, he underwent a two-step surgical correction of hypospadia a...

journal_title：Journal of endocrinological investigation

authors： Valentino R,Savastano S,Tommaselli AP,Dorato M,Scarpitta MT,Calvanese E,Del Puente A,Lombardi G

更新日期：2000-05-01 00:00:00

abstract：:Endothelins (ETs) are potent vasoconstrictive peptides released from the endothelium and other tissues, which act on target cells by receptorial calcium-mediated mechanisms. ET-1 levels are increased in diabetes, and observations suggest the involvement of ETs in the pathogenesis of diabetic angiopathy. However, it is...

journal_title：Journal of endocrinological investigation

authors： De Carlo E,Milanesi A,Martini C,Maffei P,Sicolo N,Scandellari C

更新日期：2000-04-01 00:00:00

abstract：:Patients with active Cushing's syndrome have an increased thrombotic tendency. We chose to reassess the mechanism underlying the thrombophilic state associated with this clinical condition using sensitive markers of coagulation and fibrinolysis activation in 17 patients with active disease. The results were compared w...

journal_title：Journal of endocrinological investigation

authors： Fatti LM,Bottasso B,Invitti C,Coppola R,Cavagnini F,Mannucci PM

更新日期：2000-03-01 00:00:00

abstract：:There is increasing evidence that androgen therapy in men may be effectively applied in several conditions to improve well being and health. Classical indications for androgen therapy in males are represented by primary or secondary hypogonadism, delayed puberty, aplastic anemia and that secondary to chronic renal fai...

journal_title：Journal of endocrinological investigation

authors： Gambineri A,Pasquali R

更新日期：2000-03-01 00:00:00

abstract：:Basal IGF-I levels and the GH response to at least two among provocative stimuli such as clonidine (CLO, Catapresan, 150 mcg/m2 p.o.), GHRH (1 mcg/kg i.v.)+arginine (ARG, 0.5 g/kg i.v. infusion during 30 min) and GHRH+pyridostigmine (PD, Mestinon cpr 60 mg p.o.) have been evaluated in 43 children with Prader-Willi syn...

journal_title：Journal of endocrinological investigation

authors： Corrias A,Bellone J,Beccaria L,Bosio L,Trifirò G,Livieri C,Ragusa L,Salvatoni A,Andreo M,Ciampalini P,Tonini G,Crinò A

更新日期：2000-02-01 00:00:00

abstract：:Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic reso...

journal_title：Journal of endocrinological investigation

authors： Syro LV,Horvath E,Kovacs K

更新日期：2000-01-01 00:00:00

abstract：:We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...

journal_title：Journal of endocrinological investigation

authors： Iascone MR,Vittorini S,Collavoli A,Cupelli A,Kraft G,Biagini A,Clerico A

更新日期：1999-12-01 00:00:00

abstract：:We report two patients with incidentally discovered enlarged parathyroid glands while performing neck ultrasonography (US) for thyroid nodules. The parathyroid masses were seen as hypoechoic, homogeneous, oval nodules, separated from the thyroid gland. Both patients were completely asymptomatic, although subclinical e...

journal_title：Journal of endocrinological investigation

authors： Pesenti M,Frasoldati A,Azzarito C,Valcavi R

更新日期：1999-11-01 00:00:00

abstract：:The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...

journal_title：Journal of endocrinological investigation

authors： Thodou E,Kontogeorgos G,Kyrodimou E,Salla H,Ramyar L,Vamvassakis E,Piaditis G,Anagnostopoulos N,Tzanis S,Levedis A,Rologis D,Asa SL

更新日期：1999-10-01 00:00:00

abstract：:Somatostatin has been found in the pineal gland of several animal species, which suggests that it may be involved in the regulation of melatonin secretion. Whether somatostatin has regulatory influence on melatonin secretion in man has never been unequivocally shown. We studied the nocturnal melatonin secretion in 8 h...

journal_title：Journal of endocrinological investigation

authors： Wikner J,Wetterberg L,Röjdmark S

更新日期：1999-07-01 00:00:00

abstract：:A 41-year-old male with primary hypothyroidism and a huge TSH-secreting pituitary tumor presented with a bleeding nasal mass that was initially misdiagnosed as a paraganglioma. Other unique features of the case include lack of complaints related to hypothyroidism, an extremely elevated TSH level of 3474 mU/l, and a lo...

journal_title：Journal of endocrinological investigation

authors： Ghannam NN,Hammami MM,Muttair Z,Bakheet SM

更新日期：1999-06-01 00:00:00

abstract：:A 39-year-old Danish woman was treated with an oral dose of 400 MBq 131I for a non-toxic goiter with compression symptoms. Serum anti-TPO and TSH receptor antibodies were negative before radioiodine therapy. The patient developed hyperthyroidism four months after treatment and ophthalmopathy after another three months...

journal_title：Journal of endocrinological investigation

authors： Nygaard B,Metcalfe RA,Phipps J,Weetman AP,Hegedüs L

更新日期：1999-06-01 00:00:00

abstract：UNLABELLED:Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus [Cmax] and as area under the curve [AUC]) to HEX at the doses of 1 microg/kg i.v. (HEX 1) and 2 microg/kg i.v. (HEX 2), in comparison with the responses to GHRH ...

journal_title：Journal of endocrinological investigation

authors： Guzzaloni G,Grugni G,Morabito F

更新日期：1999-05-01 00:00:00

abstract：:Reduced cardiac mass and performances are present in GH deficiency and are counteracted by rhGH replacement. GH and IGF-I possess specific myocardial receptors and have been reported able to exert an acute inotropic effect. Synthetic GH secretagogues (GHS) possess specific pituitary and hypothalamic but even myocardia...

journal_title：Journal of endocrinological investigation

authors： Bisi G,Podio V,Valetto MR,Broglio F,Bertuccio G,Del Rio G,Arvat E,Boghen MF,Deghenghi R,Muccioli G,Ong H,Ghigo E

更新日期：1999-04-01 00:00:00

abstract：:Cerebral ischemia and symptoms of stroke can occur as a rare manifestation in patients with pheochromocytoma. We describe a 45-year-old woman who was admitted because of a right-sided hemiparesis due to an ischemic lesion in the left hypothalamus. The clinical diagnosis of a pheochromocytoma was proven by highly eleva...

journal_title：Journal of endocrinological investigation

authors： Lehmann FS,Weiss P,Ritz R,Harder F,Staub JJ

更新日期：1999-03-01 00:00:00

abstract：:Thyrotoxicosis factitia, a syndrome due to the surreptitious ingestion of excess thyroid hormones, has generally been diagnosed in young or middle-aged women with psychopathological disturbances. We reviewed all the cases seen at our Institution over a 24-yr period, from 1973 to 1996. All 25 patients were women. Analy...

journal_title：Journal of endocrinological investigation

authors： Bogazzi F,Bartalena L,Scarcello G,Campomori A,Rossi G,Martino E

更新日期：1999-02-01 00:00:00

abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Guido R,Valenti S,Giordano G

更新日期：1999-01-01 00:00:00

abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components. GH insufficiency has not been recognised as a classical manifestation of this syndrome. We describe the case of a girl with APECED, who presented with four end...

journal_title：Journal of endocrinological investigation

authors： Franzese A,Valerio G,Di Maio S,Iannucci MP,Bloise A,Tenore A

更新日期：1999-01-01 00:00:00

abstract：:The association of several risk factors, obesity, dyslipoproteinemia, hepatic steatosis, insulin resistance and hypertension with Type 2 (non-insulin-dependent) diabetes mellitus and myocardial infarction has long been known and has been termed the "metabolic syndrome". In 1988 Reaven introduced syndrome X as the link...

journal_title：Journal of endocrinological investigation

authors： Johannsson G,Bengtsson BA

更新日期：1999-01-01 00:00:00

abstract：:In addition to growth hormone (GH), sex hormones are important determinants of body composition. Aging is accompanied by a decrease in free testosterone levels and, as BMI as well as fat mass increase with age (with a redistribution of body fat), whereas muscle mass decreases, it is tempting to attribute a causal role...

journal_title：Journal of endocrinological investigation

authors： Vermeulen A,Goemaere S,Kaufman JM

更新日期：1999-01-01 00:00:00

abstract：:Recombinant human thyroid-stimulating hormone (rhTSH) was developed to safely provide exogenous TSH stimulation in patients on thyroid hormone suppression therapy (THST), which is integral to long-term management of well-differentiated thyroid cancer. Such stimulation allows detection of thyroid remnant and neoplastic...

journal_title：Journal of endocrinological investigation

authors： Incerti C

更新日期：1999-01-01 00:00:00

abstract：:The enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) is higher in thyrotoxicosis. Bile-salt sequestrants bind iodothyronines and thereby increase their fecal excretion. We, therefore, evaluated the effect of colestipol-hydrochloride administration on clinical and biochemical indices of patients wi...

journal_title：Journal of endocrinological investigation

authors： Hagag P,Nissenbaum H,Weiss M

更新日期：1998-12-01 00:00:00

abstract：:1-123 metaiodobenzylguanidine (1-123 MIBG) scintigraphy is known for its high specificity in detecting pheochromocytoma and other tumors of neural crest origin. In this rare case report, we describe a definite adrenocortical adenoma that demonstrated false-positive uptake at I-123 MIBG scintigraphy and a remarkable ac...

journal_title：Journal of endocrinological investigation

authors： Letizia C,De Toma G,Massa R,Corsi A,Caliumi C,Subioli S,D'Erasmo E

更新日期：1998-12-01 00:00:00

abstract：:Glucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer,...

journal_title：Journal of endocrinological investigation

authors： Güven M,Hatemi H,Taşan E,Altuntaş Y,Ulutin T,Tezcan V,Kanigür-Sultuybek G

更新日期：1998-11-01 00:00:00